2018-05-25

封面图展示的是通过2个单独的钠原子和铯原子构建1个单一NaCs分子的装置。这个单一的化学反应发生在1个长为80毫米的玻璃细胞真空室中，通过1个显微镜物镜（封面图中右侧部分）聚焦，这些原子被激光光束捕捉并进行处理。当原子被聚集在一起后，该化学反应便由光脉冲触发。

Apparatus for building a single NaCs molecule from two individual sodium and cesium atoms. The single chemical reaction takes place in an 80-millimeter-long glass cell vacuum chamber, where the atoms are captured and manipulated by laser beams focused through a microscope objective (shown at right). The reaction is triggered by a pulse of light after the atoms are brought together.

2018-06-01

封面图上展示的是1只发育中的斑马鱼胚胎，其受精后仅仅不到1天的时间，在单一细胞的分辨率下形成我们现在看到的平铺共聚焦显微镜图像。当胚胎发育成鱼类和两栖动物时，单细胞RNA测序可以被用来生成高分辨率的基因表达活动图谱。

Tiled confocal microscopy image of a developing zebrafish embryo at single-cell resolution, less than 1 day after fertilization. Single-cell RNA sequencing can be used to generate high-resolution maps of gene expression activity as embryos develop into fish and amphibians.

2018-06-08

封面上展示的是一只雄性的婆罗洲猩猩。通过对多个猿基因组的长读测序及组合——其中包括猩猩、大猩猩、黑猩猩及2个人类的基因组——为我们展现了在每个血统中所发生基因变化的更加完整的视图。与观察到的其他猿类的表达模式相比，在人类大脑发育过程中，与基因相关的人类特有核碱基的缺失与复制的表达不同。

A male Bornean orangutan (Pongo pygmaeus). Long-read sequencing and assembly of multiple ape genomes—including those of an orangutan, a gorilla, a chimpanzee, and two humans—provide a more complete view of genetic changes that occurred in each lineage. Human-specific nucleobase deletions and duplications associate with genes differentially expressed during human brain development, in contrast to the expression patterns observed for other apes.

2018-06-15

封面图中的这个男孩名叫尤素福·阿达姆，他只有12岁，却患有晚期艾滋病，封面上的他正在尼日利亚阿布贾的Asokoro地区医院接受X光检查。尽管我们正在逐步接近“终结艾滋病”的目标，但艾滋病毒仍然在某些地区大肆破坏。强大的抗逆转录病毒药物能够阻碍病毒传播并延长患者寿命，但由于贫穷和其他社会经济因素，许多感染者并没有获取这些药物的手段。

Yusuf Adamu, a 12-year-old boy with an advanced case of AIDS, gets an x-ray at Asokoro District Hospital in Abuja, Nigeria. Although the world is getting closer to its goal of "ending AIDS," HIV still wreaks havoc in some places. Powerful antiretrovirals can thwart transmission and extend life span, but many infected people do not have the means to obtain these drugs, owing to poverty and other socioeconomic factors.